How is the theme of nature explored in Oedipus Rex?

From the outset of the drama, Sophocles establishes the
tension between acts of nature and acts of human beings.  There is a disconnect between
them.  In the Prologue, Thebes is besieged with famines, fires, and the plague. This
helps to reflect a Classical belief that the when the natural order is cruel to humanity
it is because of a disconnect between the way humans act towards the natural order or
the power of the divine.  In this case, the death of Laius is reason for this disruption
in the natural balance of consciousness.  Act I's highlight of Oedipus showing
disrespect towards Teiresias further continues this schism between how the divine order
perceives what humans do, in the form of Oedipus failing to show respect for one who can
see without sight, a natural gift.  It is also interesting to note that only Jocasta
really shows deference to the Gods, praying to Apollo to restore Oedipus' sanity.  It is
not until Act V when Oedipus feels "the weight of the Oracle."  This can be seen as
Oedipus accepting his own condition for the first time as a mortal and one who is
insignificant in comparison to the Gods.  It makes sense that this recognition happens
at this point, which is also the moment where he acts to restore order in the world and
reestablish the natural configuration and harmony that he unknowingly disrupted with his
hubris- ladened actions.