After Chuck Close had a stroke and bound to a wheelchair and paralyzed, how did his work change after this event?

I would say that one of the major ways his work changed
was that it provided further expansion to Close's understanding of photorrealism.  Close
had to reconfigure the way in which his art was created in the wake of "The Event."  In
attempting to conceive of a new manner in which work was to be displayed, the grid- like
approach actually provided a new manner in which his photorrealist style could be
conceived.  I think that this becomes one of the most interesting elements regarding his
work after "The Event."  The process by which he had to reconstruct his work was more
"digital," in a way.  He was able to use the grid setting to pixel-ate his work,
something that was not as pronounced before his illness.  In this manner, Close was able
to replicate or recreate the same photorrealist effect, although in a different way. 
From an artistic point of view, this is unique because it reflects Close's fundamental
desire to change the way in which art is both constructed and viewed.  Close's work had
always challenged conventions, and this was one more way to challenge his own challenges
of artistic conventions.  I think that another way in which Close's work changed was
that it forced him to recognize that while he could not devote a certain level of focus
in one manner, he was able to channel it into another, proving again the fluid nature of
both art and the process that gives birth to it.